Harm outcomes were rates of patients with at least one adverse event (any adverse event according to the definitions used in the primary trials) and rates of withdrawals owing to adverse events (any adverse event according to the definitions used in the primary trials).
Outcome measures Remission and response rates (benefit outcomes), as well as rates of patients with at least one adverse event and withdrawals owing to adverse events (harm outcomes).
14 This publication presents the main findings of the reboxetine trials with the aim of assessing the benefits (remission and response rates) and harms (rates of patients with at least one adverse event and rates of withdrawals owing to adverse events) of reboxetine versus placebo or SSRIs in the acute treatment of major depressive disorder.
Among the 50 patients who discontinued prematurely owing to adverse events, 13 were reported to have a movement disorder-related adverse event during the study.
Reboxetine was inferior to placebo (that is, it was associated with higher event rates) in the meta-analyses of the rates of patients with at least one adverse event and in the meta-analysis of the rates of withdrawals owing to adverse events (OR 2.14, 95% CI 1.59 to 2.88; P<0.001 and OR 2.21, 95% CI 1.45 to 3.37; P<0.001, respectively; fig 4).
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Moreover, analysis is performed of the kinetics of protein-protein interactions at physical contacts that are established between two proteins, owing to biochemical events, protein affinity adsorption forces, and protein binding forces.
Phylogenetic reconstructions also demonstrate that the plant genes involved in the formation of phylloquinone display a high degree of evolutionary chimerism owing to multiple events of horizontal gene transfer and gene losses.
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Nineteen patients (53%) were subjected to dose reduction owing to adverse events.
