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Ate1-deficient males are also infertile, owing to defects in Ate1−/− spermatocytes.
Ate1-deficient males are also infertile, owing to defects in meiotic Ate1−/− spermatocytes.
This results in asymmetric chromosome segregation and aneuploidy owing to defects in cytokinesis and aberrant mitotic exit.
Mice deficient in E2F1, for example, have excess T-cells owing to defects in thymocyte apoptosis, and E2F1 has been shown to activate the expression of Apaf-1.
Downstream intervention using nucleotide precursors could potentially circumvent a scenario in which folic acid cannot ameliorate some FOCM-related neural tube defects owing to defects in the intervening enzymes required to metabolize folic acid.
In addition to the cell lysis phenotype of GroE-depleted E. coli, it has been reported that cells with impaired GroE exhibit filamentous cell morphology owing to defects in cell division [ 27].
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Combined, these data indicate that obesity in BBS animals is owing to defect(s) downstream or at the level of LepR but upstream of melanocortin receptors in the hypothalamic leptin melanocortin axis.
In line with the specific and intimate relationship between Gab1 and c-Met, it is perhaps not surprising that mice lacking Gab1 phenocopy many of the aspects of HGF- and c-MET-deficient mice, such as early embryonic lethality owing to placental defects, reduced liver size and defects in the migration of muscle precursor cells [ 32, 61].
In addition, the difference in photocatalytic properties owing to crystal defects was observed.
To perform intracytoplasmic sperm injection (ICSI) in couples with primary infertility owing to sperm defects causing total immotility.
From the PL results, a near-band edge emission was observed in the lower O2 pressure ratio, owing to the defects that existed in the ZnO film.
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