Even with such aggressive treatment regimens, which are often associated with considerable acute and long-term side effects, about 15% of pediatric and 40% of adult T-ALL patients still relapse, owing to acquired therapy resistance, and present with very dismal survival perspectives.
MM remains a fatal disease, primarily owing to acquired resistance to anti-myeloma chemotherapeutic drugs [ 1].
On the other hand, B. longum and B. lactis showed an initial death slope, followed by a tail effect owing to acquired resistance.
Myeloproliferative neoplasms (MPNs) are clonal hematopoietic stem cell disorders in which proliferation of one or more of the myeloid lineages occurs owing to acquired somatic mutations in signal transduction pathways, which results in fibrosis of the bone marrow.
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This includes the use of platinum-based chemotherapy that fails owing to tumours acquiring the ability to repair the drug-induced DNA damage.
It is generally believed that a history of pertussis is protective against future pertussis owing to antibodies acquired by natural infection.
And because of this premise, the jury was not instructed that the means by which Chiarella acquired his informational advantageby violating a duty owed to the acquiring companieswas an element of the offense.
However, owing to intrinsic or acquired drug resistance, relapse and metastasis are common.
Unfortunately, owing to intrinsic or acquired drug resistance, relapse and metastasis are common and result in high mortality of GC.
However, a major clinical challenge is a short-term response owing to development of acquired resistance during the course of the treatment.
