Dysfunctional telomeres, either owing to critical shortening or disruption of the shelterin complex, activate a DDR, which eventually results in cell cycle arrest, senescence and/or apoptosis.
Artists as diverse as Jane Campion, King Hu, Joseph Losey, Hou Hsiao-hsien and even Clint Eastwood owe their critical esteem in part to Mr. Rissient's advocacy.
Getting a handle on who and what you owe is critical to paying them back on time.
But again, perhaps owing to some critical failure of empathy, I couldn't thrill to these scenes.
The official service pistol for the British military during the Second World War was the Enfield No. 2 Mk I.38/200 calibre revolver, but owing to a critical shortage of handguns, a number of other weapons were also adopted (first practically, then officially) to alleviate the shortage.
Although a direct connection between lncRNAs and reprogramming is still missing, owing to the critical role of Oct4 in pluripotency and ES lineage-specific differentiation, these results strongly imply a role of these lncRNAs in controlling stem cell fate.
Even though some success has been reported, failure of most of clinical trials has been attributed to the assumption that in vivo delivery is critical, owing to the toxicity and instability of molecules used (Mello and Conte, 2004).
In particular, CXCL12, which is also called stromal-derived factor-1, and its receptor CXCR4 have attracted tremendous interest, owing to their critical role in determining the metastatic destination of breast cancer cells.
Here, we studied the role of the checkpoint kinase Chk2 in mediating the in vivo phenotypes induced by telomere dysfunction owing to either critical telomere shortening (Terc deficiency) or severe telomere uncapping (Trf1 deficiency).
But his acting rarely drew critical praise, owing at least partly to the sort of films with which his career began — mostly the escapist fluff that audiences were demanding in those grim Depression days.
