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Further testing can occur only in the event of an overwhelming survival benefit in a phase II trial.
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Sometimes life support is withdrawn from infants who are dying, or who have such overwhelming illness that survival is unlikely.
ER+ positive and HER2/neu+ breast cancer cells show suppressed Notch signaling, which is probably limited by the overwhelming proliferative and survival effects of ER and HER2-dependent pathways [ 2].
The infant Jewish state fought a desperate, heroic and ultimately successful battle for survival against overwhelming odds.
More than anything, it is a game that tells an eloquent tale of survival against overwhelming odds.
Yet in the early 1980s clinicians in the US were mapping children's silence – often in the face of overwhelming evidence – as a survival strategy.
The Seven Years' War, fought in Europe by Frederick the Great of Prussia against Austria, France, and Russia, ended with his survival against overwhelming odds.
The overwhelming pattern of lower survival in more deprived groups for almost all cancers seems more persuasive than whether individual estimates of the deprivation gap are statistically significant.
This is a far from optimal situation in the intensive care environment where judicious allocation of hospital resources is required; survival with overwhelming residual neurological disability and absent or poor quality of life following insult to the central nervous system incurs expensive in- and out-of-hospital therapy and high indirect costs [ 40- 45].
Still, overwhelming is overwhelming.
Models of tree growth, recruitment and survival represent the overwhelming result of traditional observational studies.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com