Emergency situations may include massive haemorrhage, asphyxiation, severe terminal dyspnoea or overwhelming pain crisis" (p. 584) [ 4].
Early termination for the study will be recommended for evidence of overwhelming benefit (2-sided p < 0.003 favouring eplerenone) or substantive harm (2-sided p < 0.01 against eplerenone).
The results showed that positive attitudes regarding a once-weekly dosing regimen were common, with beneficial aspects perceived to include greater convenience, better medication adherence, improved quality of life, and a less overwhelming sense of treatment (p < 0.001 for all comparisons).
Still, overwhelming is overwhelming.
There are potentially several reasons for the lack of survival of the overwhelming majority of the P-element lines.
With the HITS-p cohort, the overwhelming majority of transmissions are caused via contaminated injecting or tattooing equipment (Dolan et al. 2010; Teutsch et al. 2010), so co-transmission of other pathogens is unlikely.
Giraud T, Dhainaut J-F, Schremmer B, Regnier B, Desjars P, Loirat P, et al. Adult overwhelming meningococcal purpura: a study of 35 cases, 1977 1989.
Unlike some higher education contexts such as Seery's (2015) review study on chemistry flipped classrooms, the present review cannot draw "an overwhelming agreement that students liked the approach" (p. 762) in K-12 education.
In more detail: The ANOVA revealed a main effect of experimenter gender (F[1,77] = 7.28, p = 0.009) and an overwhelming three-way interaction (F[1,77] = 37.79, p < 0.0001) (see comments in final paragraph of 'Materials and methods').
Males (109 patients; 75.2%; P < 0.0001) predominated and the overwhelming majority of cases irrespective of gender were Malays (129 patients, 88.9%) (Table 1).
