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The rapid and overwhelming onset of the HSR as observed in our patient is not compatible with the natural course of an IgE hypersensitivity reaction and points towards one of the two other mechanisms.
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Excessive activation of nuclear factor-kappa B (NF-κB) has been the key point of the inflammation overwhelming process in onset of ALI.
This is consistent with the clinical presentation of rapid-onset, overwhelming infection that has been associated with invasive CA-MRSA disease in humans [29].
This was initially because communications were severely hampered by the loss of local telephone services and the onset of overwhelming cellular phone traffic.
Still, overwhelming is overwhelming.
The overwhelming majority of adolescent-onset binge drinkers (9 in 10 male and 7 in 10 female adolescent-onset binge drinkers) continued to binge drink in young adulthood (table 1).
The onset of the overwhelming majority of conditions on the ACMG list can occur in childhood.
Maternal condyloma or genital HPV infection during pregnancy is the overwhelming risk factor for juvenile onset recurrent respiratory papillomatosis (more than 200-fold increased risk) [ 43, 70].
Age is the strongest risk factor for neurodegenerative diseases, and although there are rare cases with early onset presentation, the overwhelming majority of patients develop clinical symptoms in the later stages of their lives.
A fall will be defined as " unintentionally coming to the ground or some lower level and other than as a consequence of a sudden onset of paralysis, epileptic seizure, or overwhelming external force" [ 54].
In particular, redox-sensitive transcription factors have gained an overwhelming interest momentum over the years, ever since the onset of the burgeoning field of free radical research and oxidative stress.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com