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These mice displayed extensive damage and persistent immune infiltration of inflamed tissues, and, in the case of generalized inflammation, overwhelming mortality.
But, it is possible for on-going transmission to be masked by overwhelming mortality: a highly virulent pathogen could cause rapid host death and leave little record in prevalence measurements.
Attempts at two-thirds partial hepatectomy in zebrafish led to overwhelming mortality, with no animals surviving for two days (Kan et al., 2009) after resection; however, it remains unclear if that discrepancy represents a functional difference or simply a technical hurdle.
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Indeed, coral cover does not appear to be increasing in some Caribbean reserves [36] and the causation might include overwhelming coral mortality, a lack of reserve impacts on fish, or a lack of herbivore impacts on the benthos if other processes, such as nutrification or sedimentation, were to dominate the response of algae.
This is hugely significant as metastasis is the overwhelming cause of mortality in breast cancer patients, but a complete understanding of its molecular and cellular determinants remains elusive[ 36].
Although invasion and migration are the overwhelming causes of mortality in patients with solid tumours, our understanding of their molecular determinants is limited (Fidler, 2003; Weigelt et al, 2005; Gupta and Massagué, 2006).
Breast cancer metastasises though the lymphatic system or via the circulatory system and is the overwhelming cause of mortality in patients with malignancies, causing 90%% of deaths in solid tumours [ 53].
The evidence that insecticide treated nets (ITNs) reduce malaria risk and mortality is overwhelming [3].
For those who develop fulminant, overwhelming post-splenectomy sepsis, mortality rates approach 50% [ 7], and those who survive may be left with significant morbidity.
A statistically significant increase in all-cause mortality has overwhelming clinical significance which cannot be compensated for by a simultaneous reduction in non-fatal events.
An ideal system to ensure compliance with guidelines has not been reported, but a post-splenectomy registry may provide a systematic approach to this population, and could be cost-effective in terms of avoidance of mortality and overwhelming post-splenectomy sepsis [ 33].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com