It might increase neuronal excitability and ectopic firing in the acute stage, and then evolves to permanent nerve injuries with overwhelming injury discharges to the central nervous system and induces subsequent central sensitization in the chronic stage.
In Phase I, death occurs immediately or quickly as a result of overwhelming injury [ 5].
The concomitant suppression of Th1 priming after skeletal muscle injury may be an endogenous mechanism that aims to compensate for such overwhelming injury-induced inflammation.
Actin exposed at the site of overwhelming injury may act as a sink to exhaust the supply of plasma gelsolin, in turn allowing redundant inflammatory cascades unfettered opportunity to wreak havoc upon multiple organ systems.
Although there remain a large proportion of trauma victims who die early from overwhelming injury, trauma patients who survive their initial injury do not die from their injury per se, but from an overwhelming inflammatory dysregulation leading to organ dysfunction, nosocomial infection, and ultimately multiorgan failure [ 2, 3].
It is suggested that apoptosis can be induced indirectly by cells that undergo necrosis in response to overwhelming physical injury and may be a driving force for cell proliferation during tissue regeneration in many different organisms [ 55].
By reacting with lipids, DNA, and proteins via direct oxidative reactions or via indirect radical-mediated mechanisms, ONOO− can trigger cellular responses ranging from subtle modulations of cell signaling to overwhelming oxidative injury that commits cells to necrosis or apoptosis [ 69].
Despite the overwhelming burden of injuries, there is limited data on injury epidemiology and its outcomes in India.
The Nets, a team that was hit with an overwhelming run of injuries last season, are hoping to be at full strength for the playoffs now that MacCulloch is back.
The overwhelming majority of injuries caused by a variety of activities as well as high-velocity accidents typically involve moderate to severe trauma to the musculoskeletal soft tissues.
