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"The county must be required to submit a wholesale revision, one that is focused on confronting the exclusionary zoning that is an overwhelming impediment to fair housing choice throughout white Westchester".
As haploinsufficiency is relatively rare [ 10], reduced copy number is not by itself an overwhelming impediment to large scale loss, as is evident from analysis of surviving duplicates in the Arabidopsis, rice, teleost, and yeast genomes [ 9, 11- 13].
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Still, overwhelming is overwhelming.
The geopolitical complexities are daunting, and the structural impediments to change seem overwhelming.
In fact, lack of knowledge and inconsistent practice pertaining DM diagnosis, evaluation and management among care providers, long intervals between patient visits and limited consultation time due to overwhelming heavy patient load constitute major impediments to attainment of diabetes related goals of therapy [ 8, 9].
A key difference in deeply blue California is that few Republicans see any realistic chance of unseating Gov. Jerry Brown, a Democrat whose overwhelming lead in the polls has been a major impediment to Kashkari's fundraising.
Zapu enjoyed overwhelming support among the Ndebele and was seen as an impediment by the leadership of Zanu-PF.
The impediments to transformation are the competing needs, concerns, agendas, risks, capabilities, legalities and other potentially overwhelming challenges.
The slight speech impediment.
Sound overwhelming?
Parents are an impediment.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com