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TNFR1 is involved in death signalling; however, TNF-induced cell death only plays a minor role, compared to its overwhelming functions, in the inflammatory process.
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The overwhelming part of Drosophila Myc targets control ribosome biogenesis and protein synthesis, which, therefore, constitute the core and presumably primordial function of Myc proteins.
Its feat in continuing to function despite overwhelming obstacles was part of the event's high drama.
Still, overwhelming is overwhelming.
As an initial impression, our finding of global presynaptic/postsynaptic up-regulation (receptors, transporter, turnover) might then suggest an overwhelming increase in 5HT function.
Time to first ventricular activation is the overwhelming determinant of circulatory function, regardless of whether this is the left or right ventricular lead.
They told of an inability to function, an overwhelming anxiety, an inability to organize their thoughts, and trouble making decisions: tasks that "normally seemed easy, seemed huge" so that "getting through the day was horrendous".
This alternate, caspase-independent form of cell death most likely relates to the extensive nature of MOMP such that often all mitochondria undergo permeabilisation leading to a progressive and overwhelming loss of mitochondrial function (Lartigue et al, 2009).
Concomitant with this, there is an overwhelming expansion of their putative functions, and both, the fine structural conformation as well as the different functions are probably determined by the numerous actin binding proteins.
The public sector is to be left only with "core custodial functions" in the overwhelming majority of jails.
However, in computing M x) for the large networks of E. coli, S. cerevisiae and B. subtilis, we face the problem that the overwhelming majority of the regulatory functions (also termed regulatory phrases) that determine the combined effect of the regulators on their target genes are unknown.
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