Sentence examples for overwhelming cell death from inspiring English sources

When the stress remains overwhelming, cell death pathways may be activated.

CD4+ and CD8+ cells deficient in ATG3, ATG5 and ATG7 cannot proliferate after they are activated [ 95, 96], and Atg5−/− lymphocytes fail to repopulate the periphery due to overwhelming cell death [ 93].

However, unlike the response of the TNBC cells to the combination therapy where there was overwhelming cell death, the combination therapy treatment of MCF10A and MCF7 cells resulted in an initial reduction in cell numbers, but a gradual recovery of cell growth over three days.

Overwhelming cell death could be observed at the concentration of 100 μg/mL, and the migration was difficult to be evaluated.

Although overexpression of APP and A β causes neuritic beading in transgenic mice, it does not produce overwhelming levels of cell death.

Conversely, the sreA = 0 knockout led to iron overload (SDM of LIP = 1) and cell death by overwhelming ROS SDMM of ROS = 1) under high iron conditions, but had no defects under low iron conditions.

H2O2 is believed to induce intracellular defense mechanisms that tend towards production of more endogenous antioxidant, but when overwhelming, it leads to apoptosis and cell death [ 1].

Under high superoxide conditions, model knockouts of any of the four oxidative stress-related species had a high cell death phenotype due to overwhelming ROS.

The signaling pathways activated by these reactive species either enhance cytoprotective processes or trigger cell death in the case of overwhelming stress.

Shifts from cell apoptosis to necrosis are known to occur in primary hepatocytes, where the inhibition of caspase activity converts apoptotic to necrotic cell death in the presence of an overwhelming death stimulus from staurosporine (Feng and Kaplowitz, 2002).

These abnormalities trigger ER stress-dependent events which consist of the production of chaperone proteins that attempt to prevent cellular demise [14] and/or activation of cell death cascades when ER stress is too overwhelming [16], [56].