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As I read on to the book's largely satisfying conclusion, I couldn't get out of my mind one of its many weird bits of whale science — during the 1950s military researchers became interested in whales because of their ability to filter important communication signals from the overwhelming background chatter of marine shrimp.
In order to select rare events over the overwhelming background, central systems with high-performance, high bandwidth, flexibility and configurability are necessary, that minimize dead time while maximizing data collection reliability.
Because MS measurements of bacterial proteins against overwhelming background of host proteins are still technically challenging (Schmidt and Volker, 2011), vast majority of work thus far falls into examination of the bacterial proteome in bacteriological media.
The large scale analysis of cellular phosphorylation by liquid chromatography-mass spectrometry (LC-MS) is challenging due to the low stoichiometry of phosphorylation, causing phosphopeptides to remain largely undetected in the overwhelming background of non-modified peptides.
Eventually, it is no longer feasible to identify the target beads from the overwhelming background, regardless of how much laser power is applied.
The Cyp46a1−/− mouse thus provides an excellent opportunity to profile low-level oxysterols, with potential biological activity, without being obscured by the overwhelming background of 24S-hydroxycholesterol.
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Current protocols and technologies enrich rather than purify CTCs, imposing limitations on the feasibility and reliability of measuring CTC-specific markers within the overwhelming WBC background.
Furthermore, the massive number of troops would have led to an overwhelming amount of background noise.
"There's some support for limiting multi-round magazines, and overwhelming support for background checks".
Shifting to today, Steven Caple Jr.'s Creed II builds on the same story, but on a more basic plot level: opportunities to face off with oldish names (the son of Rocky IV's Drago is the big bad), daddy issues in the background, overwhelming odds in the foreground, and an underdog-to-topdog finish.
Domestic reform without a background of overwhelming foreign crisis has not been attempted in sixty years.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com