Sentence examples for overwhelming alteration from inspiring English sources

These discrepancies could be explained by the fact that genetic activation of AKT induces an overwhelming alteration in cardiac gene expression profile [ 46] which might have not yet developed in our acute experiments.

However, owing to the overwhelming molecular alterations that have been reported in pancreatic cancer, there is increasing focus on targeting molecular pathways and networks, rather than individual genes or gene-products with a combination of novel chemotherapeutic agents.

Chronic UV exposure leads to cumulative DNA alterations overwhelming physiological DNA repair mechanisms.

Still, overwhelming is overwhelming.

Histologically, buboes are typically heavily infected and display overwhelming inflammatory and necrotic alterations [6], [8], [13], [14].

However, most of the research has focused on the particularities of individual cancer types that result from the overwhelming number of genomic alterations that can drive these phenotypes.

While the overwhelming evidences pointed to the alteration of actin cytoskeletal organisation as the common target, several reports showed that the induction of apoptosis is mediated through JAK2/STAT3 signaling pathway.

If you're looking at somebody with cancer or some systemic disease, which is an overwhelming one, where there may be alterations in consciousness, then you may have somebody process of dying being a gradual withdrawing from the world, which is happening over the time of days, weeks or even months.

But an overwhelming majority of Americans oppose "germline engineering" in humans — the alteration of genes in the first cells of the blastocyst.

But an overwhelming majority of Americans oppose "germline engineering" in humans — the alteration of genes in the first cells of the blastocyst.

Depression is described as "an alteration in mood ranging from a mild sadness to overwhelming despair.