Sentence examples for overwhelming activation from inspiring English sources

However, overwhelming activation of granulocytes and monocytes can contribute to significant cell and tissue damage [7].

It is not yet clear if this astroglia-proliferation is due to bacterial toxins or to overwhelming activation of early immune responses [36].

Undesirable overwhelming activation of immune responses may lead to harmful consequences.

The LktA protein induces the overwhelming activation of neutrophils leading to production of cytokines that mediate tissue injury [ 12- 15].

The complement system is a key in innate immunity, but overwhelming activation of complement can lead to severe tissue injury.

Among the multifaceted mechanism of pathogenesis of dengue, high DENV burden was reported to circumstantially associate with DHF in hosts with secondary infection [ 37, 38], while the overwhelming activation of Th2 cytokines was documented in the development of DHF in dengue patients of primary and secondary infections alike [ 17, 20– 20].

However, overwhelming complement activation usually is required to produce clinically evident intravascular haemolysis [ 29].

We would hypothesize that testing of mast cell activators at the time of dengue diagnosis, which is generally after the onset of fever and after the development of systemic infection, would be a promising strategy to limit overwhelming systemic activation of mast cells while allowing the early and protective mast cell responses to occur without hindrance.

These data provide overwhelming evidence that activation of PKC enzyme is essential for lipid metabolism [82].

One possibility is that the negative signal provided by CEACAM1 during the early phase of the immune response may prevent an overwhelming T cell activation in WT mice.

Concluding these observations and our results gained from the murine S. aureus peritonitis model (Fig. 9A, C) we suggest that an overwhelming HIF-1 activation (and subsequent VEGF secretion) is detrimental in severe infections.