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The overt weakness is that real incomes continue to be squeezed, despite the fall in unemployment.
Medved means bear in Russian and the worst way to respond to a bear is to display overt weakness or to scarper in different directions.
To assess subtle deficits in motor function in patients lacking overt weakness, we administered the grooved pegboard neuropsychological test to 12 enrolled subjects for both dominant and non-dominant hands.
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In some but not all patients with cardiomyopathy due to MYH7 mutations, but without overt muscle weakness, cores may be identified in skeletal muscle fibers [ 23].
These studies were designed for assessment during the early postnatal period in mice as small as 1 2 g in an effort to understand motor unit function prior to onset of overt motor weakness.
20– 25 Importantly, electrophysiological studies have rarely been obtained in early symptomatic or presymptomatic cases, but in the four patients described, electrophysiological measures appear to be preserved prior to onset of overt motor weakness.
The decreased capacity for SOD1G86R mice to endure acute physical exercise that solicits anaerobic metabolism in muscle occurred before any measurable muscle weakness or overt denervation (Figs 1 and 2).
CMAP and MUNE measurements were obtained in untreated SMNΔ7 mice (n = 8) and control mice (n = 8) at days 3 13 to understand the natural history of motor unit function prior to overt onset of motor weakness and continuing through end-stage disease (Table 2).
Application of NIV prior to the onset of respiratory muscle fatigue or before there is significant atelectasis might avert a "vicious cycle" of increasing dyspnea, dysfunctional respiratory pattern and mechanics, and weakness culminating in overt respiratory failure.
Here we review some of the non-adaptive immune mechanisms that may be responsible for muscle weakness in the absence of overt inflammation, and we provide evidence that skeletal muscle, but not inflammation, is an active participant in the progression of muscle disease in these disorders.
We observed that smoking, in the absence of overt lung disease, is not accompanied by muscle weakness and wasting or changes in contractile properties of the quadriceps muscle after taking into account age, sex and physical activity.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com