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According to the neural simulation theory [1] actions are not confined to an overt stage but also contain a covert stage.
Once reached stage 5, overt stage, T2DM is diagnosed.
Stage III, the overt stage, is characterized by the presence of clinical signs of heart failure [ 1, 12- 15].
T2DM is chronic with nature history lasting for more than twenty years, which has been divided into five stages: latent stage, transition stage, impaired glucose tolerance stage (IGT), impaired fasting glucose stage (IFT), and overt stage [ 4].
The difference between overt Stage I-III cancers and the three low malignant potential, borderline tumors (IGB) is significant (P = 0.033 by one-tailed Student t-test) because low malignant potential ovarian neoplasm is a nonmalignant but epithelial process.
Because of the difficulties in treating PC at a clinically overt stage and the restricted sensitivity of imaging modalities to detect PC at an early stage, advancing the treatment to a subclinical stage may overcome the current problems in treating patients with PC of colorectal origin.
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It is the view of the authors that POI can be taken to encompass occult, biochemical and overt stages, whereas POF is best considered as only the final stage of POI.
Additionally, in proteinuric kidney diseases, including overt stages of diabetic nephropathy, proteinuria filtered from glomeruli enhances ER stress responses in proximal tubules, leading to progression of tubulointerstitial lesions [ 53].
Finally, several groups of hematopathologists have validated the specific histological BM pattern characterizing PV and confirmed and extended the notion that there are no significant differences regarding BM morphology between mPV and overt stages of PV.
The difficulty in detecting cellular immune responses against autoantigens in RA patients [ 14- 16], together with the failure of some T-cell directed immunomodulatory treatment strategies [ 17- 22] and impressive successes of therapeutic tumour necrosis factor (TNF -α blockade in RA, appeared TNF -αlicate macrophages as the major effector cells in the clinically overt stages of RA [ 7, 23].
NOD-Ig μnull mice, which lack functional B cells, show the typical lymphocytic infiltrations in the salivary glands but do not develop hyposalivation until transfer of purified human SS-IgG or parental NOD-IgG, suggesting a crucial role for antibodies in an overt clinical stage of the disease rather than the initial phase of lymphocyte infiltration [ 53].
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