Overt haemoglobinuria due to marrow infusion develops in 75%to100%0% of patients who receive cryopreserved marrow infusions [ 45, 46].
Recent concern have been expressed on the long term sub-threshold exposure of bio-accumulative heavy metals producing different clinical manifestations from overt poisoning due to a single or limited exposure to a higher toxic dose [ 4, 5].
Some knockouts show transient neonatal hypoglycaemia, whereas some dominant-negative transgenic mice go on to show overt diabetes due to loss of β-cell mass following initial hypersecretion (Miki et al., 1997; Seino et al., 2000).
Further, overt disease due to NTM is uncommon in the southern hemisphere [ 13] and asymptomatic MAC infection of healthy persons detected by identical skin testing methods is no more common in Africa than in the United States [ 8].
The clinical relevance of recognizing mPV was demonstrated in a recent study on 66 JAK2-mutated patients younger than 40 years who revealed a higher risk of thrombosis compared with a control group of 97 cases with overt PV due to the less frequent use of phlebotomies or cytoreductive treatment.
By contrast, EMT-marker expression was not found in patients with overt proteinuria due to MCD [ 45, 46, 52], in keeping with the fact that the high proteinuria seen in MCD is rarely associated with interstitial fibrosis or renal failure [ 53].
Thus, the finding of 5HTA1 and SLC6A4 in the hyperacusis/tinnitus network but not in the hearing impaired/tinnitus network might support a serotonergic mechanism underlying a central gain origin of tinnitus and hyperacusis, in the absence of overt deafferentation due to hearing loss.
Recently published guidelines in Europe recommended VCE as the initial examination for overt OGIB, mainly due to its safety [ 11].
We observed no increases in nonneoplastic histopathologic lesions in either species suggestive of overt tissue damage due to the oxidant properties of Cr VI).
Amongst those infected, about 20 40% have clinical features of some cardiac injury (chronic chagas cardiomyopathy, CCC), and 15% ultimately develop overt heart failure due to left ventricular dysfunction [ 5– 9].
