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We assessed admission glycemia, glycated hemoglobin, mean blood glucose concentration on days 1 and 2 in 200 patients with a first AMI but without overt disturbances of glucose metabolism.
To further test the model, we evaluated the adaptation of islets isolated from two donors with overt disturbances in glucose metabolism (older donors, high HbAlc or a history of diabetes; ESM Table 2).
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Although undisturbed areas are free of overt disturbance, they may be impacted by other factors (i.e., invasive weeds) or other land-use practices that reduce the wildlife value (i.e., over-grazing), neither of which are included in our definition of disturbed areas.
Animals from such lines did not manifest an overt disturbance of crypt-villus homeostasis, indicating a threshold level of transgene expression for the previously described dramatic dysmorphogenesis phenotype [ 10].
ADHD is a condition that translates itself as overt behavioural disturbances in pre-school infants, school age children, adolescents and adults.
Although a pharmacological approach can be effective in managing certain psychiatric behaviors (eg, hallucinations, paranoia, depression), for some patients, overt behavioral disturbances such as wandering, resistance to care, agitation, or repetitive vocalizations, are less amenable to drug management (Class et al 1997).
Second, it is wrong to assume that emotionally undeveloped children exhibit overt symptoms of disturbance, deviance or developmental delay.
Regression analysis showed a significant positive relationship between sleep disturbances and overt emotional expression coping, between tiredness/fatigue and avoidance coping, and between nausea and religious coping.
The wide scope of these actions, and the profound metabolic and hormonal shifts induced by CR has led to efforts at identifying natural or synthetic compounds that mimic the effects of CR in the absence of overt metabolic and endocrine disturbances or reduced caloric intake.
Kotsoris et al. reported that urinary disturbances predated overt multi-infarct dementia by more than 5 years in up to 50% of patients [ 26].
Some recently published trials also indicated that lifestyle modification and various pharmacological agents can delay or prevent the development of glucose disturbances to overt diabetes.
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