We postulated the increase preceded overt disease.
Individual and joint patterns suggest a genesis well before overt disease.
Only a subset of infected persons will develop overt disease; most remains asymptomatic despite lifelong colonization.
Elucidating the mechanisms that allow natural hosts to coexist with SIV without overt disease may provide crucial information for understanding AIDS pathogenesis.
Participants were 8 normotensive older men and women (5 female, 3 male, 72.5 ± 4.7 years old) with no overt disease or medications that affect nitric oxide metabolism.
C. neoformans is found worldwide in various environmental niches, generally associated with avian guano or vegetation2, 3. Exposure to C. neoformans usually does not cause overt disease and the infection may lead to an asymptomatic latent state4, 5.
Much of our knowledge of the effects of mutations found in CHIP comes from mouse models because individuals with CHIP do not have overt disease, hence they do not enroll in clinical studies.
Depletion of reparative capacity as reflected by loss of CPCs may presage overt disease as exemplified in this pre-diabetes model.
Worldwide HIV-1 vaccine efforts are guided by the principle that HIV-specific T cell responses may provide protection from infection or delay overt disease.
One theory of aging and disease development is that chronic injury (pathology) results in activation of regenerative processes and initial repair, with overt disease arising only after exhaustion of reparative capability leads to inadequate repair.
This means that we will be able to predict what illnesses individuals may suffer, and determine strategies to halt progression to overt disease.
