Exact(22)
We have determined that it is unlikely that enz is required prior to overt differentiation.
trpm7b508 appears to affect melanophore development prior to overt differentiation, as most melanophores fail to appear in trpm7b508 homozygotes.
Furthermore, although a slight diminution of CD34 fluorescence intensity was observed, overt differentiation as measured by the maturation marker CD11b was not induced (Figure 3D).
Prior to overt differentiation, chromatophore precursors are referred to as chromatoblasts, and can be identified by expression of genes specific to one or multiple chromatophore sublineages.
Expression continues in premigratory and migratory neural crest cells, and persists until slightly after overt differentiation of neural crest derivatives, such that by 24 hpf, crestin-expressing cells are found throughout the embryo [58].
Double mutant analysis of enz with trpm7b508, a mutation previously demonstrated to affect melanophores just prior to overt differentiation [67], revealed that embryos homozygous for mutations in both genes resembled trpm7b508 single mutants with respect to the melanophore phenotype.
Similar(38)
(E ) We propose that BMP imposes a posterior positional identity whilst delaying both EMT and overt mesoderm differentiation but permitting surface ectoderm differentiation.
Wholemount in situ hybridisation analysis revealed Mro to be expressed in the embryonic male gonad from approximately 11.5 days post coitum, prior to overt sexual differentiation.
Overt chondrocyte differentiation was not altered, in that we observed normal expression patterns of Collagen II and Collagen X (Fig. S6).
We reasoned that such a tissue should broadly co-express most factors required for neural crest chondrogenesis, including upstream transcriptional regulators and downstream markers of overt cartilage differentiation.
One surprise is that no clear SOX9-interaction site was found in the Sox6 gene, which together with Sox5, is required for overt chondrocyte differentiation and requires SOX9 for expression [8].
Write better and faster with AI suggestions while staying true to your unique style.
Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com