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And some cases of overt deficiency -- notably of vitamins B12, folate, iron, and calcium -- are seen.
Few of these are bad enough to present as overt deficiency syndromes, but even nominal deficits of key nutrients may compromise health.
No increase in the risk for cancer with GH supplementation has been reported in young patients with overt deficiency.
And finally, any of the markers for vitamin B-12 deficiency may be used if the goal is to distinguish between a normal vitamin B-12 status and an overt deficiency.
Whereas the absence of essential nutrients from the diet results in overt deficiency often times with moderate to severe physiological decrements, the absence of bioactive substances from the diet results in suboptimal health.
We and others perceive holoTC as an early marker of vitamin B-12 deficiency, but final proof of this concept would require a study in which a cohort of patients is followed as their vitamin B-12 status shifts from normal to overt deficiency.
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Indeed, our participants were almost unanimously complaining about overt deficiencies in this domain.
As genetic deletion of Taspase1 in the mouse produced no overt deficiencies, inhibition of Taspase1 may offer novel anticancer strategies, including the treatment of leukemias.
Furthermore, MC2R knock out mice have overt aldosterone deficiency and hyperkalaemia despite preservation of a normal zona glomerulosa.
Any elevation in homo-cysteine, even at levels where overt folate deficiency is not an issue, may be undesirable because it is a risk factor for chronic disease.
As the target range of 50-100 μg/L is approached, testing may be repeated more frequently to preempt the development of overt iron deficiency.
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