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Indeed, our participants were almost unanimously complaining about overt deficiencies in this domain.
As genetic deletion of Taspase1 in the mouse produced no overt deficiencies, inhibition of Taspase1 may offer novel anticancer strategies, including the treatment of leukemias.
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And some cases of overt deficiency -- notably of vitamins B12, folate, iron, and calcium -- are seen.
Few of these are bad enough to present as overt deficiency syndromes, but even nominal deficits of key nutrients may compromise health.
No increase in the risk for cancer with GH supplementation has been reported in young patients with overt deficiency.
And finally, any of the markers for vitamin B-12 deficiency may be used if the goal is to distinguish between a normal vitamin B-12 status and an overt deficiency.
Whereas the absence of essential nutrients from the diet results in overt deficiency often times with moderate to severe physiological decrements, the absence of bioactive substances from the diet results in suboptimal health.
We and others perceive holoTC as an early marker of vitamin B-12 deficiency, but final proof of this concept would require a study in which a cohort of patients is followed as their vitamin B-12 status shifts from normal to overt deficiency.
The 1988 Food and Agriculture Organization of the United Nations and World Health Organization (FAO/WHO) Expert Consultation report (13) indicated that there were three states of folate nutrition: folate adequacy, impending folate deficiency, and overt folate deficiency.
Despite some concerns, western vegetarians and vegans have not been found to suffer from overt zinc deficiencies any more than meat-eaters.
For example, a school-based feeding programme may work by short-term hunger relief in young children in a low-income rural setting where famine has produced overt nutritional deficiencies, but for teenagers in a troubled inner-city community where many young people are disaffected, it may work chiefly by making pupils feel valued and nurtured.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com