Sentence examples for overt defect from inspiring English sources
Of note, PP1α-null animals display no overt defect and, thus, appear phenotypically normal (Dr. Angus Nairn, unpublished results).
We did not observe any overt defect in general neuronal structure in apl-1 tm385 apl-1 tm385, therefore defects in the develethalt of the neuronaL1setherefore not likely to contribute to the phenotype.
No overt defect was identified in the Nf1L7CKO cerebellum, confirming that Nf1 is relatively dispensable in the development of Purkinje cells.
A HFD increased gut permeability to FITC-dextran, but we found no overt defect in gut permeability (to FITC-dextran) in NOD2−/− mice.
Other double mutants exhibited exencephaly (n=1/32; 3%; Fig. 2F) or had only a tail defect (Fig. 2G; n=2/32) or no overt defect (n=2/32).
In summary, although we cannot rule out that the localization of additional kinetochore components, not considered in our analysis, is affected when Aurora B is inhibited, we suspect that reduced localization of checkpoint components is unlikely to be caused by an overt defect in the assembly of the kinetochore.
Despite endothelial deletion of CD146, CD146EC-KO mice did not exhibit overt defects or detectable abnormalities in organ morphology upon analysis by light microscopy (data not shown).
While individual germline deficiency of either Rap1a or Rap1b did not cause overt defects in mouse lens, conditional double deficiency (Rap1 cKO) prior to lens placode formation led to an ocular phenotype including microphthalmia and lens opacification in embryonic mice.
While no overt defects in mitosis were observed in Hdac3−/− MEFs, including normal H3Ser10 phosphorylation, DNA damage was observed in Hdac3−/− interphase cells, which appears to be associated with defective DNA double-strand break repair.
Ehd3 /– animals showed no overt defects, and exhibited no proteinuria or glomerular pathology.
Breeding of the chimeric mouse with C57BL/6 strain yielded heterozygous mice which did not show any overt defects.
