Exact(2)
While SIEVE analysis fails to attribute significance (p < 0.05) to PCP-induced alterations in the overt concentration of many metabolites in this cluster, GSVD analysis reveals that the relationship between these metabolites is significantly altered by PCP treatment (p < 0.001), highlighting the specific metabolic pathways that may be disrupted in the PFC of PCP-treated animals.
While SIEVE analysis fails to attribute significance (p < 0.05) to PCP-induced alterations in the overt concentration of many metabolites for many metabolites in this cluster, the PCP/Control ratio suggests that the levels of many of these metabolites are markedly altered by PCP-treatment.
Similar(58)
Importantly, these effects were completely independent of ERRα expression or overt alterations in the concentration of mitochondrial proteins over the time course of the experiment.
There is a spectrum of iron deficiency in pregnancy ranging from iron depletion without anaemia (absent iron stores with a normal haemoglobin concentration) to overt anaemia [ 3].
Analyses of the arsenic content of 206 tube wells (95% of the total) showed that 56.8% exceeded arsenic concentrations of 50 micro g/L, with 19.9% > 300 micro g/L, the concentration predicting overt arsenical skin lesions.
Thus, in a mixed-sex population at risk for, but without, overt type 2 diabetes, concentrations of large neutral amino acids were related to insulin resistance, and concentrations of free fatty acids and by-products of fatty acid oxidation were related to an impaired pancreatic response.
Only recent studies have dealt with the action of Aβ at concentrations without overt neurotoxicity on synaptic properties [3].
We found that inhalation of O3 for a brief period causes concentration-dependent overt and latent neurophysiological and electrophysiological effects in SH rats, a strain of rat known to demonstrate cardiac effects in response to inhaled ambient PM, diesel exhaust particles, and acrolein (Farraj et al. 2009, 2011; Hazari et al. 2011).
Second, higher systemic doses of riluzole might increase the chances of hepatotoxicity as the ALS-driven increase in P-gp and BCRP seems to be tissue specific, and using elacridar may be the way to just increase riluzole CNS concentrations without overt toxicity.
In this experiment, PC axons did not change significantly their growth pattern (Fig. 4E, E17+GCflipflip vs E17, Chi square or Fisher exact tests always P>0.30), showing that the main effect of GCs on the growth mode of PC axons is exerted through contact-mediated factors, while high KCl concentration has no overt influence.
We estimated that about 2.1 million and 0.6 million people could be drinking As contaminated water above 10 and 50 μg/L, respectively, while 0.048 million could be at risk of drinking As-contaminated water above 300 μg/L, the concentration predicted to cause overt arsenical skin lesions.
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