The two posterior clusters were primarily associated with action processes, in particular with phonology and overt speech (posterior-dorsal cluster) and with rhythmic sequencing (posterior-ventral cluster).
When analyzing Alzheimer's disease data set, we detected three overt outliers detected by hiearchical clustering analysis, and remove those samples from analysis (Figure S7).
In addition to focal lesions of overt myelin damage, small focal clusters of activated microglia are frequently observed in the normal appearing white matter (NAWM) of MS patients, in the absence of any detectable blood-brain barrier breakdown, leukocyte recruitment or myelin damage [ 6, 7].
Three MGUS presented an excess of osteoclastic resorption (OR) in the vicinity of clusters of tumour cells and developed overt B cell malignancies, chronic lymphocytic leukaemia, Waldenström's disease and MM respectively.
TRAT1 was selected as the most highly correlated gene from cluster 1 (Fig. 4), while FGL2 was selected as the second most highly correlated gene in cluster 2, and of more established immunologic interest than TC2N and less overt connection to immune response polarization than IFNG, the other two genes derived from cluster 2 that contribute to the 16-gene polarized immune response classifier.
The cytological features of ADCs include clusters of tumor cells with prominent nucleoli, predominate or overt mucin production, vacuolated cytoplasm, acinar formation and other features characteristic of glandular differentiation (Figure 2).
Via a high-throughput screening protocol, the authors identified a number of compounds, which included novel flavonoid-derivative molecules and a cluster of structurally related kinase inhibitors that interfered with primordium migration without overt toxicity in vivo.
These aptamers did not exhibit overt sequence or predicted structure similarity, so we employed bioinformatic methods to propose novel aptamers based on analysis and clustering of secondary structures.
