The insights central to these reports and pamphlets came to prominence when the authors of the 1999 MIT report on the Status of Women in the Faculty of Science declared that women continue to face gender discrimination in this "post-civil rights era" but that it does not operate through the formal, overt barriers to participation that had mobilized activists in the 1960s.
While "overt barriers" no longer exist, she said, women now face challenges that are harder to detect.
Another important finding is that in our universal health care setting, with no overt financial barriers to screening, the percent of all diabetes that was undiagnosed was lower than reported in past literature (2, 24).
Overt market access barriers and regulatory constraints at the national and sub-national level increasingly and blatantly tilt the playing field to Chinese companies' advantage.
There is also, however, a barrier to overt government interference that may not apply elsewhere.
Collectively, the study supports the concept that the intestinal epithelium maintains a physiological state of inflammation with respect to continuous microbial exposure, which serves to maintain a tight intestinal barrier, without engendering overt inflammatory responses that would compromise barrier function.
However, collagen fibrils are not observed in chronic cuprizone lesions, which is consistent with a lack of blood brain barrier disruption or overt tissue destruction (Sofroniew and Vinters, 2010).
This study supports the concept that the intestinal epithelium has evolved to maintain a physiological state of inflammation with respect to continuous microbial exposure, which serves to sustain a tight intestinal barrier while preventing overt inflammatory responses that would compromise barrier function.
Dynamic susceptibility-weighted contrast (DSC, perfusion-weighted) imaging will disclose an increased relative blood volume as a consequence of the onset of neoangiogenesis, which may be detectable before an overt breakdown of the blood brain barrier occurs [ 5].
