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However, we saw no overt alterations in the organization of actin or microtubules in MiTMAB-treated neurons (data not shown), apart from the failure of migrating neurons to resolve their trailing processes at the cell rear.
Importantly, these effects were completely independent of ERRα expression or overt alterations in the concentration of mitochondrial proteins over the time course of the experiment.
Fifteen-week-old KO mice showed no overt alterations in testicular weight and histology although spermatogonial populations were reduced (Supplementary Figure S1).
At least three genes can be effectively suppressed simultaneously in cultured intact human pancreatic islets without disruption of islet architecture or overt alterations in function.
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Of course, we know that the artist can mediate the image; she can manipulate our version of the truth in countless ways -- lighting, exposure, camera angle, diffusion, overt alteration, context and omission -- to construct a narrative that comports with artistic intent.
No overt alteration of sodium channel gene expression was identified to directly explain the arrhythmias observed in KO mice.
Adult ctsk−/− mice, which do not display overt phenotypic alterations when fed a normal diet, displayed a partial resistance to weight gain and to development of dyslipidemia when challenged with a HFD.
Because detailed analysis of the DFMs in lms mutant flies showed that the DFMs are present and lack any overt morphological alterations, it appears that lms is needed for the acquisition of the requisite functional properties of these muscles rather than their formation and morphogenesis.
In other Dsg2-producing tissues such as intestinal mucosa, liver and endometrium no overt pathological alterations were observed.
HRBECs are samples from women who, based on extensive epidemiology, are identifiable as predisposed to malignant progression, even before overt cytopathological alterations are present.
Endothelial cells express the intermediate filament vimentin [ 7], and although no overt phenotypic alterations were observed in the original report of vimentin null animals [ 8], subsequent studies revealed defects in endothelial barrier function [ 9].
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com