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As we point out in the revised manuscript, they may be functionally abnormal, yet conditional deletion of torsinA from these cells does not cause overt abnormalities (Yokoi et al., 2011).
No overt abnormalities that could indicate mutagenic effects of NP-Pt were observed.
In a recent study, we have revealed that certain VKH patients with normal visual acuity have overt abnormalities when tested by multifocal electroretinography [7].
Immunohistochemical analysis of homozygous mutant testes of adult mice revealed no overt abnormalities.
Similarly, genetic disruption of SERT also does not produce overt abnormalities [33], [34].
However, on C57BL/6J, XX Map3k1ΔKD/ΔKD homozygous adult females (n = 2) were fertile and homozygous XX embryos exhibited no overt abnormalities of ovary development.
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We did not observe any overt abnormality in cortical layering at P7 in SynIII KO mice.
All miR-133a-1 miR-133a-1 miR-133a-1viable and fertransgenicut overt abnormicety.
However, we noted no overt abnormality in the pattern of synaptopodin protein in Vangl2 mutant glomeruli.
While the findings also do not demonstrate any overt abnormality in germ cell numbers or development in MBP-exposed animals, some changes were detected at birth in a minority of animals that could indicate an effect, especially as only six animals were evaluated at birth for these parameters; this requires clarification.
It was reported that CX3CR1- or CX3CL1-deficient mice did not exhibit any overt histological abnormalities and behavioural abnormalities.
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