In summary, we have demonstrated that flavones drive neutrophil apoptosis in a caspase-dependent fashion to override survival factor-induced delay of apoptosis by down-regulating the key neutrophil survival protein Mcl-1 in a proteasomal-dependent fashion.
This ability of flavones to override survival factors and drive apoptosis is important to ensure that such neutrophil apoptosis-inducing effects are not lost at sites of inflammation in vivo.
There are many ways to describe the sort of suffering that overrides a survival instinct that has evolved over millions of years, but "easy" isn't an obvious one to go for.
We would like to point out that the compound is active even in the presence of FCS, which shows that blocking the IGF system overrides the survival signals from other factors.
"Even though I surfed big waves growing up, at some point the survival thing overrode the thrill for me.
But animal suicides are rare - they would have to override their instinct for survival right?
I don't know how a human being can override the sort of survival instincts our brains put in place to run into a burning building without the professional training and protective gear that professional firefighters receive, but somehow, this kid found whatever was needed deep within himself to do so.
Similarly, human neutrophil granulocytes express CD137 constitutively, and crosslinking of CD137 overrides the pro-survival effects of GM-CSF and induces apoptosis [34].
On human eosinophil granulocytes CD137 expression is inducible by an unidentified T cell-derived factor, and crosslinking of CD137 overrides the pro-survival effects of GM-CSF and IL-5 [33].
Advanced tumors typically have increased survival signaling that overrides anoikis, suggesting that cells could survive following extrusion.
