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In the presence of FBP, FIR is an overriding negative regulator of c-myc (Liu et al, 2001), functioning by neutralizing FBP's stimulation of the p89/XPB 3′–5′helicase of TFIIH by an as yet undescribed mechanism.
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At the optimal dose, receptor clusters are capable of overriding negative signaling by primarily recruiting Syk.
Our results demonstrate that optimal secretory responses of mast cells and basophils depend on the formation of receptor aggregates capable of overriding negative regulatory signals.
We have to actively override negative instincts, and that's strenuous.
Overrepresentation of CCGG sites might be explained by a positive effect of their methylation with MTases that overrides negative effect of probable DNA cleavage with REases.
TSPYL5 can override senescence-like proliferation arrest and oncogene-induced senescence and contribute to cell transformation suggesting its role as a negative regulator of p53 function [ 61].
Myostatin (MSTN) is a negative regulator of skeletal muscle mass.
However, GS3 is a negative regulator of grain length (Fan et al. 2006).
CKX is therefore regarded as a negative regulator of cytokinin metabolism.
Protein tyrosine phosphatase 1B (PTP1B) is a negative regulator of insulin signaling and NO production.
These studies also indicated that SUB1A-1 might be a negative regulator of OsSUB1C.
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