The ability of acitretin to increase intracellular concentrations of ATRA appears to override its capacity to stimulate the expression of proteins that degrade RA.
The yield of XynA was minimally affected by lengthening the expression period from 4 to 6 h, suggesting that the proteolytic capacity did not override the pro-folding capacity (Supplementary Figure S6).
This often overrides the sublime capacity to absorb positive emotions and all that is beautiful.
Instead, based on published work, agonists and antagonists of specific signaling pathways (some already developed and some FDA approved or in clinical trials), could be used systemically to quickly reset tissue stem cells residing in old organs to their "young" robust regenerative capacity, e.g. overriding the aged niche and its altered molecular cues.
Sometimes, we are told, people's vulnerability is such that their desire to believe a deceiver's hopeful message overrides their capacity to question it.
In a mouse model, overexpression of MnSOD resulting in overproduction of H2O2, was found responsible for damaging the β-cells through overriding the limited hydrogen peroxide-inactivating capacity [46].
Self-control has been defined as the capacity to alter one's responses, e.g. by overriding impulses in order to bring behaviour in line with goals and standards [1], [2].
In Washington, the Republican-controlled House Committee on Natureleasedurces last week releasedraftraft bill that would appoint an oversight board with the capacity to override Puerto Rico's own government as it tries to trim the island's debt.
As a direct consequence of their capacity to override oncogene-induced senescence and apoptosis, Twist1 2 cooperate in vitro and in vivo with mitogenic oncoproteins for malignant transformation.
Their additional response inhibition capability afforded to them by virtue of the training would provide sufficient capacity to override the automatic, cue-driven response to stimuli to drink alcohol.
