Rather than attempt to disable these barriers one by one, a more pragmatic clinical approach would be to deliver factors that can broadly override immunosuppressive barriers in the tumor environment.
Like getting bureaucratic institutions (and regular human beings) to override artificial barriers between nation states, (how about forced immigration?), self interest and paranoia blocking the sharing of vital scientific information and the moral dilemmas that crop up in a crisis that's larger than one culture's ideology can process constructively.
Some clinicians attempted to override these barriers and intervene in normative processes so they could refer patients to specialist services (box 1H).
This suggests that at least part of Myc and Ras cooperativity is based on a "cross-pollination" mechanism where Myc abrogates the predominating tumor suppressing activity of Ras and vice versa, thereby together overriding two major barriers to tumor development.
This is now the one great issue for the future of the country, overriding everything else, jumping party barriers as never before, forging some very strange alliances.
The study also talks about factors such as "dissonance reduction," when human beings avoid conflict, and "takeoff issues," when an issue reaches such a high status in the public eye that it breaks down social barriers and becomes widely discussed, overriding people's habit of "dissonance reduction".
This suggests that therapies that target peripheral IL-1 could be beneficial in brain injury, potentially overriding the need to deliver drugs across the blood-brain barrier.
At a shallow part of the accretionary wedge, overriding soft sediments easily deform and seamounts would behave as rigid objects (Dominguez et al.1998) or barriers (Kodaira et al.2000; Hirata et al.2003).2003
Certification of an EIA with unmitigated significant environmental impacts requires a formal Statement of Overriding Considerations that documents the project's compelling benefits and the specific economic, legal, social, or technologic barriers that make mitigations or alternatives infeasible.
