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In Avery et al's study the key themes around which consensus was reached on importance included computerised alerts; the need to minimise spurious alerts; making it difficult to override critically important alerts; having audit trails of such overrides; effective computer-user interface; and the need to be able to run safety reports[ 10].
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The commission claimed this provided an "effective override", replacing a more conventional basis on which to calculate the proper value of royalties.
The overriding principle for effective rheumatic pain management is symptom relief with maintained function, rather than palliation [ 9].
Currently available data indicate that effective DBS overrides pathological bursts, low frequency oscillations, synchronization, and disrupted firing patterns present in movement disorders, and replaces them with more regularized firing.
Importantly, the override option is more effective than the financial incentive.
In particular, SYK-specific siRNA as well as SYK inhibitor PCT were effective in overriding a checkpoint-dependent mitotic arrest provoked by NOC treatment in both B-lineage lymphoid and non-lymphohematopoietic human cells.
There are no effective means of blocking or overriding the effects of TNF on muscle cells besides immunological treatments aimed at TNF [36].
However, large scale implementation of HPV vaccination is still challenging, and even when effective, it will not override the need for cervical cancer screening.
Then, the gas mobility in the override zone has been reduced greatly and effective diversion occurred.
Consequently, the effective relative motion between the overriding plate and the subducting plate around the locked area was broadly suppressed compared with other regions, thereby reducing the cumulative seismic slip of M7 8-class earthquakes.
But stifled by unintended negative consequences and high degrees of alert override, 9 10 they have not been as effective in preventing prescribers from making errors, as previously hoped.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com