This could be correlated with menopause onset, a complex series of physiologic events that normally take place around that age and that can have a profound impact on bone resorption as well, while sharing similar pathogenetic mechanisms with age and possibly synergizing, and overriding age effects on bone mass [ 22].
Any effect may have been overridden by ageing effects because O. davisae males rapidly lose mating performance (Fig. 2B).
In our analysis, gene expression was not dominated by genotype-specific changes that might override subtle age-related changes in gene expression.
In the context of late-onset AD, chronic inflammatory stress to neurons would, with advancing age, override this protective mechanism leading to the same pathological changes as those observed at earlier age in familial AD cases.
Opioid addiction also seemed to override the effects of age and gender on mortality.
Having a relationship where the woman is treated with respect, and involved in decision-making has been shown to override the influences of age, socioeconomic status, ethnicity, preparation for childbirth, the birthing environment including continuity of care, and medical interventions on childbirth satisfaction.
We measured the rate of total overrides, rate of appropriate overrides, medications overridden, and the reason(s) for override.
However, the normal bone phenotype observed in 34-week old Lef1+/− female mice favors the hypothesis that androgen signaling, much like aging in females, overrides the skeletal sensitivity to Lef1 haploinsufficiency by restraining bone turnover.
Although Robin Marantz Henig's excellent article ended on a note of resignation, given the proper tools even the most anxious children in this age of neuroplasticity can override their neural presets and make a world of difference in their lives.
Thus, these zebrafish provide a model system that overrides the limitations of mice for aging studies, namely the need to breed for several generations (which can be expensive and time-consuming) to obtain the desired phenotype.
