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However, upon infection with the intestinal parasite Toxoplasma gondii, CD4+ T cells respond against the pathogen as well as the translocating commensal bacteria, demonstrating the ability of the immune response to override tolerance to commensals [ 52].
Inefficient clearance of these modified proteins in an inflammatory environment, conveying 'danger signals' to the immune system, might in combination with the appropriate MHC haplotype override tolerance mechanisms and activate autoreactive T cells.
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Interestingly from an aging standpoint, transgenic mice that overexpress BAFF have increased numbers of MZ cells and high levels of autoantibodies in their serum, prompting Groom and coworkers [ 40] to hypothesize that excess BAFF in these animals overrides a critical tolerance checkpoint by providing a survival signal to self-reactive B cells.
Generic recommendations #2 to #4 are related to dose; they provide generic guidance but can be overridden by CPG-specific rules, e.g. tolerance of some drugs is not dose-dependent.
Since TSLP is required for the initial expansion of B1 and B2 bone marrow B-cell progenitors [ 15], it can also be postulated that an increase in systemic TSLP levels in HCV-infected patients enhances B-cell lymphopoiesis and the expansion of specific B-cell subsets, leading to override of some of the controls underlying B-cell tolerance.
An amendment would not just be for the UK; it would be for all 47 member states in each of which popularism and tolerance of systematic rights violations could masquerade as "sovereignty" by means of an override.
Tolerance of established queens is thought to occur because the queen's fertility overrides information regarding colony membership.
Tolerance breeds tolerance.
Practice tolerance".
Absolute tolerance!
An override will be difficult.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com