We conclude that oncogenic effects override tissue-specific differences, at least for the mutations, tissues, and phenotypes studied herein.
Only when systemic blood flow can no longer increase to compensate for peripheral vasodilation and arterial blood pressure starts to decrease does sympathetic control override tissue-driven blood flow regulation [ 31].
We conclude that, at least for Ras V12/scrib and the tissues examined here, oncogenic effects appear to override tissue-specific differences to produce neoplasms with similar mitotic indices, resistance to IR-induced apoptosis, increased aneuploidy, and sensitivity to a chemotherapeutic agent.
It would be interesting to examine other tissues and oncogenic mutant combinations using various drivers, to see if the override of tissue-specific differences by oncogenic transformation is universal.
One negative aspect with the cross-linked donor keratoplasty procedure was the tendency to override the host tissue if vertically misaligned or over tightened, since, unlike in conventional keratoplasty donors, the compressed edge did not broaden under tension, while the host edge was deformed.
This feedback loop is regulated: cell-shape derived stresses could be overridden by imposed tissue level stresses, showing how competition between subcellular and supracellular cues control microtubule behavior.
This happened not simply because the implanted cells carried genetic information from the donor embryo and grew into what they were "programmed" to be, but because the installed cells released molecular signals and persuaded the neighboring host tissue to override their resident genes, and switch species allegiance.
This means that the LD cycle can be overridden in peripheral tissues by other zeitgebers (time cues), allowing animals greater flexibility in responding to demands of the environment [ 2– 4].
It is possible that the relatively small tissue sample size overrode the FSTL1 tissue difference between the sexes.
Evidence has accumulated that the disease progress triggers catabolic responses that override anabolism at the peripheral tissues.
These results indicate that if these repair systems are circadian-controlled at the organismic level, this control mechanism is lost or overridden by homeostatic mechanisms in tissue culture.
