Sentence examples for override cell from inspiring English sources

Consistent with the ability to override cell cycle checkpoints, it has been observed that genomic instability is increased by latent EBV [29], and is probably attributable in part to the ability of EBNA3C to override a mitotic spindle checkpoint [30].

Their observation that tissue level stress can override cell level stress was also documented in a recent paper from Jacques et al. (2013).

This initial burst of proliferation is followed by the activation of at least two tumour suppressor pathways, the p53 and p16/Rb pathways, which counteract the mitogenic activity of ras and eventually override cell proliferation.

It has been proposed that a cell size checkpoint operates to maintain a minimal cell size prior to mitosis to ensure daughter cell viability but that external, developmental inputs often override cell autonomous size checkpoints [ 19, 34, 35].

Certainly, the ability of E7 to override cell cycle regulation (stimulate S-phase progression) by interaction with the pocket protein family, including the retinoblastoma tumor suppressor (pRb) is critical [ 8], together with the cooperating ability of E6 to counteract apoptotic pathways induced as a natural response to the unscheduled S-phase entry mediated by E7 [ 9].

We have recently reported that a hallmark of highly malignant PDGF-B-induced gliomas is their in vitro ability to override cell-cell contact-mediated inhibition of proliferation [ 25].

Importantly, the absence of NG2 did not significantly affect the ability of gliomas to be maintained for long term in culture, to override cell-cell contact inhibition of proliferation forming cell foci in vitro and to regenerate a glioma after orthotopic transplantation, all features representing functional proxies for high malignancy [ 25].

The role of HSF1 in carcinogenesis includes protecting cancer cells from programmed cell death, overriding cell cycle checkpoints and enhancing metastasis [ 9- 11].

Amongst these, Myc-mediated inhibition of Miz-1 transcriptional activity by Myc Max heterodimers is clearly a central pathway by which Myc overrides cell growth control [ 44- 46].

Although E6 induces proteasomal degradation of the tumor-suppressor p53, thereby compromising cell-cycle arrest and apoptosis, E7 overrides cell cycle checkpoints at the level of cyclin-dependent kinase inhibitors and the retinoblastoma tumor-suppressor protein (pRb).

We consider that overexpression of Aurora-A enables esophageal cancer cells to override the cell cycle check point without repairing DNA damage induced by CRT and enter mitosis, resulting in the occurrence of mitotic catastrophe.