The E469Q substitution seems likely to disrupt the interaction with R246 thereby altering specific rates in the ATPase cycle but potentially within boundaries that do not overly impact function.
Because modeling the complex relationship between genes and functional labels with a single transformation matrix may be overly restrictive, we group functions into different clusters and learn a separate projection model for each cluster.
Our definition of QoL was not overly-inclusive; we required that studies had used a QoL or HRQOL scale that assessed several domains of functioning.
One problem in particular is overly-specific function predictions which we address here with a new statistical model of the relationship between protein sequence similarity and protein function similarity.
Since the pursuit of a protein with a specific function without additional constraints is perceived as overly difficult, the function-design problem is usually restricted to the search for an amino acid sequence that assumes a target 3D structure (Kuhlman et al., 2003; Park et al., 2004), assuming that this structure will entail a specific function.
The patients were similarly overly optimistic about function, with the majority of the group expecting no limitations (58/111, 52%) or only slight limitations (48/111, 43%) after surgery, but with only 20%and30%0% patients, respectively, achieving such a status.
This is a desirable property in the PM if it is to function as a 'repair patch' for an overly strained surface having a cracked CM.
As to the package, I am not overly fond of long function names; the authors should consider dropping the data source abbreviations from the function names in a future update/revision of the package.
The high variance was because LOO-CV as objective function caused overly complex models (Additional file 1: Figure S5 and S6).
In Arabidopsis, the salt overly sensitive protein 1 (SOS1) functions in Na+ exclusion from root epidermal cells into the rhizosphere, which also plays a role in retrieving Na+ from the xylem stream under severe salt stress (Shi et al. 2002).
