Sentence examples for overloaded heart from inspiring English sources
However, inhibition of Tgfβ signalling in the pressure overloaded heart has also been found to attenuate myofibroblast proliferation and collagen deposition (Lucas et al., 2010).
In short, our in vivo studies agreed with the findings of Williams and Braunwald [ 2] regarding the prophylactic effect of digitalis on the hypertrophy of the pressure overloaded heart.
In this article, we will focus on the latter possibility and review recent data from different rodent models showing the induction of a TH-inactivating enzyme in the chronically overloaded heart.
Reduced TH signaling in the hemodynamically overloaded heart could in principle result from changes in the expression of TH receptors or their co-factors; by diminished active TH uptake through its transporters; by the reduction of plasma T3 levels that is seen in severe illness, including advanced heart failure; or by changes in cellular metabolism of TH.
When we determined dP/dt min as a parameter of cardiac relaxation, we noted that in pressure overloaded heart with increased expression of thyroid hormone receptor alpha or thyroid hormone receptor beta, a very significant increase in the speed of diastolic relaxation occurred, however complete normalization was not achieved.
Our results indicating that in the control mouse the prophylactic effect of nontoxic ouabain concentrations on the pressure overloaded heart is due to the drug's interaction with the α2 isoform of cardiac Na+/K+-ATPase is also significant when we consider the possible relevance of the present animal studies to the therapeutic use of digitalis in man.
Moreover, mTOR overactivation has been shown to cause increased mitochondrial biogenesis and accumulation of reactive oxygen species in distinct model systems[36], suggesting that the activation of mTOR pathway might be responsible for the detrimental effects of MEF2C activation and vice-versa to the beneficial effects of MEF2C depletion in the mechanically overloaded hearts.
Though a number of studies that followed [ 3– 5] either confirmed or questioned the above findings and conclusions, the issue of whether or not digitalis has a prophylactic effect on the growth of the overloaded hearts seems to have disappeared from the subsequent literature.
However, the effects of this inhibitor on late-stage pressure overload hearts remain unclear and controversial.
Our results show that (a) safe doses of ouabain prevent or delay cardiac remodeling of pressure overloaded mouse heart; and (b) these prophylactic effects are due to ouabain binding to α2-isoform resulting in the selective activation of PI3Kα.
Recently, improper trafficking of junctophilin (JPH -2 on an altered microtubule network caused t-tubule derangements and calcium mishandling in a pressure-overload heart failure model.
