First, it is well established that glucose overload imposes oxidative stress to cells and that chronic hyperglycemia leads to various organ damages.
** It is difficult for the reader, given the overload of elucidation imposed upon the basic text, to maintain much momentum, and, indeed, one finds welcome refuge from the tedium and harshness of some Biblical passages in the companionable contemporary voice of the learned commentator.
It is difficult for the reader, given the overload of elucidation imposed upon the basic text, to maintain much momentum, and, indeed, one finds welcome refuge from the tedium and harshness of some Biblical passages in the companionable contemporary voice of the learned commentator.
Taken together with our recent data, we suggest that hepatic FGF21 is a general stress responsive factor that targets adipose tissue for normalizing local and systemic metabolic parameters while alleviating the overload and damaging effects imposed by the pathogenic stress on the liver.
Serum BNP is elevated due to ventricular wall stress imposed by volume or pressure overload.
This stress-activated FGF21 expression may underlie the generally beneficial effects of FGF21 through alleviating liver overload such as steatosis and counteracting potential liver damage imposed by a variety of metabolic and cellular stresses [ 9, 10].
Mimicking a volume overload towards the heart, the underlying pathophysiology might be different from aortic banding that imposes pressure overload.
The effect of its elevation is to counteract the overload and potentially damaging effect in both liver and the entire organism imposed by the stress.
The hindlimbs of winter birds may similarly be overloaded during jumping and unable to meet the increased power requirements imposed by their mass.
The hemodynamic overload generated by MI imposes mechanical and neurohumoral modifications on cardiac walls, triggering complex biological responses that culminate in tissue remodeling.
