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Patients with β-thalassemia intermedia, a less severe form, do not require chronic transfusions (i.e., nontransfusion dependent thalassemia), but still develop iron overload as a consequence of chronic suppression of the synthesis of the iron regulatory hormone hepcidin by ineffective erythropoiesis [ 1, 2].
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This latter behaviour parallels the observations made in otherwise normal organs in which a pressure overload arises as a consequence of an obstacle to the venous outflow, such as in the liver of patients with right heart failure [15] and in the spleen in case of portal hypertension, both in animal models [16] and in vivo [17, 18, 19].
But I can't say I experienced "cute overload" as a result of watching her antics.
Secondary/acquired iron overload diseases develop as a consequence of iron loading anemia, thalassemia and sideroblastic anemia.
Osteoarthritis (OA) is a degenerative disorder caused by mechanical overload and/or a consequence of imbalanced biological events between cartilage degradation and synthesis [ 15].
RV systolic function is initially preserved with RV pressure overload, but diastolic dysfunction occurs as a consequence of myocardial hypertrophy and remodelling [14].
Intracellular Ca2+ overload can occur in cardiomyocytes as a consequence of ischemic injury or other stresses, leading to contractile dysfunction and ultimately cell death via apoptosis or necrosis through activation of proapoptotic Bcl-2 family members and opening of the MPTP [ 80].
Don't go on a cheese overload, as much as you may want to.
As a consequence of overloading and poor management, the SD had no vegetation and a poor dewatering capacity, which resulted in anaerobic conditions favoring CH4 emission.
These observations suggest that both arrhythmias often co-exist in endurance athletes, and common flutter may be secondary to right atrial dilatation as a consequence of volume overload.
The defining feature of HOCM is a high pressure difference between the aorta and ventricle due to LVOTO caused by septal hypertrophy, therefore it is possible that local dysfunction may occur as a consequence of pressure overload secondary to the hypertrophy triggered by contractile protein mutations.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com