The design of these agents was based upon energy minimization and structural overlay studies of the generic azepin-2-one structure 3 with the crystal structure of arylacetamide κ agonist 1, ICI 199441.
The docking and the overlay studies revealed a number of favorable aromatic-aromatic and aromatic-aliphatic interactions as shown in Figure S3 provided in the Supporting Information [ 33].
To cross-check whether the developed pharmacophore model is consistent to the active site residues of caspase-3, we performed the overlay studies.
We examined the potential direct interactions of Beclin 1 ECD with cardiolipin by a variety of biochemical and biophysical methods, including lipid overlay studies and isothermal titration calorimetry.
However, pull-down and binding-overlay studies presented here suggest Arabidopsis PEX5 can interact with PEX14 in a PTS1-cargo independent manner.
In this paper, based on a large sample of flow data collected from operational network, we study overlay topology properties of different P2P applications from complex network perspective, including BT, Thunder, and UUSee.
Based on the GIS overlay analysis, this study recognizes the distribution of essential patches, and constructs the structure of essential patches in urban green greenbelt systems by a combination of point, line, and surface elements.
To determine whether Bam32 and TAPP1 from amphioxus perform the same functions as their counterparts from vertebrates, we used a protein-lipid overlay assay to study the interaction between these proteins and phospholipids.
