Previously reported mechanisms of action for LRP1b, including the regulation of the urokinase (uPAR) and platelet-derived growth factor (PDGF) receptor trafficking at the membrane level [8], [9], overlap with the functions of expressed and unmutated LRP1 in tumor tissues.
This is in part attributable to partial overlap between the functions of genes associated with DC differentiation.
That is not to say that there is no overlap in the functions of NF-κB and p53-regulated genes.
By contrast, there was little overlap for the functions of multiple interacting TFs, except within brain and cancer and between these 2 tissue types (Additional File 6).
Although there is clear overlap in the functions of the members of this family of transcriptional regulators, REL seems to have an important role in the survival of activated CD8+ cells [ 5].
With substantial overlap between the functions of many cytokines, and frequently multiple antagonists for any given agonist, the ability to compensate for a certain amount of divergence in production of individual cytokines is significant.
A related issue concerns a task-induced overlap between the functions of understanding a funny punch line and deciding whether it is funny, since these processes are not the same.
The high photosensitivity of leaves of the vte1 npq1 pdx1 triple mutant compared to leaves of the vte1 npq1 and pdx1 mutants suggests that there is some overlap in the functions of vitamin B6 and the zeaxanthin-vitamin E duo. Figure 8 shows that pdx1 plants are able to tolerate high light, provided the stress is not too severe.
These results suggest that the mechanism whereby Lhx2 immortalizes hematopoietic stem/progenitor cells might partly overlap with the function of Lhx2 in the development of a variety of organs.
The mild sensitivity towards ICL-inducing agents suggested that SpFan1 is implicated in ICL repair, but that its role overlaps with the function of other components of the DNA repair machinery.
A spliced form of the mRNA from this gene partially overlaps the function of synaptojanin 1 (Synj1) in nerve terminals, with additional roles in neurons and other cells [ 61].
