Sentence examples for overlapping substrates from inspiring English sources
On the other hand, CYP3A5 is known to be polymorphic and have overlapping substrates with CYP3A4 (26– 28).
Moreover, Akt and SGK possess analogous substrate specificities and are likely to phosphorylate overlapping substrates to promote proliferation.
USP4 and USP15 are also the only catalytic DUBs known to interact with the spliceosome [ 9– 11], with more than eleven splicing factors identified as overlapping substrates [ 2].
As a consequence, these PTPs have different as well as overlapping substrates and thus may fulfill complementary as well as redundant roles in health and disease [ 34].
In mammalian cells, five different long-chain acyl-CoA synthetase proteins have been described, with specific and sometimes overlapping substrates and subcellular localizations [ 32].
Matrix metalloproteinases are a family of calcium- and zinc-dependent endopeptidases that share amino-acid sequences, structural domains, and overlapping substrates.
Many of these isoenzymes have overlapping substrate specificities and therefore their potential physiological functions may overlap.
In particular, we have been interested in both the activation and inhibition of the three commonly studied isoenzymes, ALDH1A1, ALDH2 and ALDH3A1, as their distinct, yet overlapping substrate specificities, present a particularly difficult challenge for inhibitor discovery and design.
Because Oat1 and Oat3 have overlapping substrate specificity, ex vivo preparations of CP from Oat1 and Oat3 mice were used to isolate the individual transport function of each, respectively.
We also did not observe a genotype-specific effect on the gene expression of other dehydrogenases with partly overlapping substrate specificity to VLCAD, the mitochondrial MCAD and LCAD as well as the peroxisomal AOX.
As under catabolic conditions the mice develop hepatic and muscular symptoms [10]-[12] [10]-[12]hesized the same for the kidneys despite the existence of an enzyme wethypothesizedg substhete sameiforithe the long-chain acyl-CoA dehydrogenase (LCAD) [6],[15].
