However, studies of the R. etli regulons RpoE4 and PF00052-ECF have identified a unique sequence motif, which has been recognised for both ECF-type sigma factors, resulting in a large number of overlapping regulated genes [ 35].
The VI is defined as follows: (2) where is the VI between tissue x and tissue y, I x and I y are the number of individually regulated tissue-specific PAS clusters in tissue x and tissue y, respectively, and is the number of overlapping regulated tissue-specific PAS clusters in tissues x and y simultaneously.
A trans-eQTL that overlaps Eae23a regulated a large number of small RNAs and implicates a master regulator of transcription.
No other double mutants exhibited higher blebbing than the parental single mutants, indicating that END3, PKC1, and ZRT1 could potentially function in overlapping pathways regulating minisatellite stability during stationary phase.
Each cell type has its own bone marrow differentiation paradigm, as well as distinct, yet often overlapping pathways regulating their development, migration, activation, survival and death (Bochner and Schleimer 2001).
Overlapping genes regulate the expression of the genes involved through translational coupling in operons (Normark et al. 1983; Cooper et al. 1998, Zheng et al. 2002) and transcriptional regulation (Wagner et al. 2002), play an important role in genome compaction (Miyata and Yasunaga 1978; Sakharkar et al. 2005), and may be involved in the creation of new genes (Keese and Gibbs 1992).
Because type I and II IFNs regulate overlapping sets of IFN-regulated genes (IRGs), it is possible that some patients may worsen with IFNβ treatment.
A network analysis of only the 77 regulated overlapping genes in WT and Ercc1 -/Δ glomeruli also nicely shows the particular networks regulated in both aged glomerular datasets.
The read-through of overlapping genes is regulated by the ICP27 protein, which helps in the recognition of the internal polyA signals, resulting in differential transcript lengths [ 16].
The fact that treatment with BMP2 or TSA resulted in identical cell fates was reflected in the gene expression data by a significant overlap of regulated genes.
To identify an overlap of regulated genes within TSA and BMP2 treatments, two-set Venn analyses were performed, intersecting TSA 6 h, TSA 24 h, BMP2 6 h and BMP2 24 h experimental sets, respectively.
