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Neurons are highly specialized cells that have to accurately follow a large number of overlapping guidance cues during the development of the central nervous system.
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"A proliferation of national approaches, as well as overlapping and competing voluntary international standards and guidance, has led to difficulties in interpretation and implementation for companies operating in different countries and markets".
We also found to a degree, as Schulz et al. [ 13] observed, that there was limited guidance on how to deal with overlapping categories or classes.
This is reflected in overlapping content of the CONSORT-PRO [20] and PRO-specific guidance for protocols currently in development: SPIRIT-PRO extension (Standardised Protocol Items for Randomised Trials) [23, 24].
Are you getting the guidance you need to cope with a continuing health problem or multiple overlapping problems?
Furthermore, we note that while the axon guidance pathway SNPs genotyped in the ALS and PD datasets were partially overlapping, that there were many SNPs unique to either dataset.
Tumor cells release axon guidance molecules [ 59], and other neurotrophic factors which have sometimes an overlapping function in tumor vascularization (neoangiogenesis) and lymph vessel development (lymphangiogenesis) [ 60].
These computational models suggest that molecular guidance cues and neural activity may, at least to some extent, play more overlapping and independent roles in neural development than previously thought.
And today I can announce that we will also: Make it vastly easier and cheaper for businesses to meet environmental obligations - by March 2015 Defra will have slashed 80,000 pages of environmental guidance saving businesses around £100m per year; as well as Help house builders by cutting down 100 overlapping and confusing standards applied to new homes to less than 10.
E4H provides evidence-based guidance for the development of local policy that addresses social and environmental determinants of health in the overlapping domains of the social, built, economic, and natural environments.
The overlapping cast includes Laurie Metcalf, Dennis Boutsikaris and Jessica Hecht.
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