Interestingly, 5 overlapping functions were discovered between the JA and UA groups, one overlapping function (amino acid metabolism) was discovered between the JA and JU groups, and 2 overlapping functions (gastrointestinal disease, renal and urological disease) were discovered between the UA and JU groups.
When researchers generated a mROR1/mROR2-deficient mouse, they found a more severe phenotype than mROR2−/− alone, leading the authors to conclude that mROR1/2 have a redundant, yet none overlapping function in development (Nomi et al., 2001).
By contrast, the loss-of-function tba-1 allele appears nearly wild-type, likely due to overlapping function with other alpha-tubulins.
Male and female interactions typically show a limited amount of overlapping function.
Third, the conclusions had the possibility to be disturbed due to the existence of overlapping function of the other ABC transporters.
This indicates that N-cad provides the essential features to maintain tissue architecture and function which implies fully overlapping function of E- and N-cadherin in the alveoli.
However, AtLYK5 shares overlapping function with AtLYK4 and, therefore, Atlyk4/Atlyk5-2 double mutants show a complete loss of chitin response.
Furthermore, avocado mesocarp could be used to determine the preference for PDAT1 and to explore its overlapping function with DGAT1 in TAG synthesis.
Thus, rather than relying on one single protein for controlling p53 activity, mESCs may have a set of proteins with overlapping function to ensure that p53 is kept under control.
In sphingomonads Sphingobium sp. SYK-6, Novosphingobium sp. strain PP1Y, N. aromaticivorans strain DSM12444, and another Novosphingobium strain with sequence-related homologues to Lig enzymes, strain B-7, it appears that metabolism of α-keto-β-ether-linked compounds is achieved via catalysis by multiple Lig β-etherases with overlapping function.
