Most recently, mutations in RAD21, a structural protein in the cohesin complex, have been found in children with a spectrum of disabilities overlapping with the CdLS syndrome, presenting with milder cognitive impairments consistent with a so-called coesinopathy.
The high prevalence of disabilities, the overlapping between mental and physical diseases and disabilites, and the high frequencies of multiple disabilities have implications for the management and rehabilitation of these patients.
We also are supporting research to explore how reading disorders overlap with other disabilities, such as math or writing disabilities or attention deficit hyperactivity disorder (ADHD).
KCNH1 mutations have been identified in patients with Zimmermann-Laband syndrome and Temple-Baraitser syndrome, as well as patients with uncharacterized syndromes with intellectual disability and overlapping features.
Our results are in accordance with recent studies that suggest that frailty is distinct from, but overlapping with, comorbidity and disability [ 5, 9- 17, 17, 20].
Overlapping of pain and disability as perceived by the patients has been reported in different populations [ 30, 31] and may affect the structure and dimensionality of the questions and domains of the measures that did not have factor analysis as a part of initial validity analysis.
Disability overlaps the clusters referred to as "class" and "age" and the vast majority of people with disabilities are also poor (Wisner et al. 2012).
A second region revealed suggestive linkage for both full-scale and verbal IQs on 6p25.3-22.3 (LOD score 3.20 for full-scale IQ and 2.33 for verbal IQ), overlapping marginally with the 6p22.3-21.31 regimplicatedated in reading disability and dyslexia.
We used an array of 85 health-related deficits covering major health dimensions including depression, cognition, morbidity, physical performance, and disability to construct several deficit indices (DIs) with overlapping and complementary sets of deficits to test robustness of the estimates.
Intellectual disability (ID) and autism spectrum disorders (ASDs) are complex neuropsychiatric conditions, with overlapping clinical boundaries in many patients.
This highlights that although some investigators recognize that frailty, comorbidity, and disability are distinct entities [ 28, 47, 70], for others they are overlapping.
