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Crystallographic overlap studies and pharmacophoric analysis indicated that diarylpyrimidine (DAPY -based HIV-1 NNRTIs showeDAPY -based binding mode and pharmacophoric features as iNNRTIsarylshowedes (Iasimilarother class of potent NNRTIs.
We identified 332 relevant literatures via electronic searches, the overlap studies were excluded, and finally 19 studies on randomized controlled trials (RCTs) were left for analysis which involved 3148 patients in total (who were included in LAM therapy groups).
Similar(58)
One overlap study used the data from one trial [ 20] to investigate concentrations of adipokines and apoptosis [ 21].
The latter assumption may not be fully justified for a series of periodic "overlapping" studies.
Overlapping studies were shaded together.
For the outcome depression screening resulting in treatment, both reviews undertook meta-analyses of imperfectly overlapping studies.
To minimize problems in meta-analysis arising from double-counting of cases, overlapping studies were divided into two categories, as shown in Additional file 2: Studies.
Studies with potentially overlapping study populations were excluded.
Two sets of overlapping study populations were identified 19, 21, 25, 26 among the eight qualified studies, so the less inclusive study for each overlapping was excluded accordingly 21, 25.
One study was excluded because the number of cases for each exposure category was not presented [ 13] and another study was excluded due to an overlapping study populations [ 17].
After reviewing each original paper and extracting data, 7 publications were excluded including two studies on CIN [36,41], three for lack of available data [37-39] [37-39]r case-oney study [35] and one for overlapping study [40].
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